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1

Nucleotides, Part LXIII, New 2-(4-Nitrophenyl)ethyl(Npe)- and 2-(4-Nitrophenyl)ethoxycarbonyl(Npeoc)-Protected 2′-Deoxyribonucleosides and Their 3′-Phosphoramidites – Versatile Building Blocks for Oligonucleotide Synthesis

Holger Lang, Margarete Gottlieb, Michael Schwarz, Silke Farkas, Bernd S. Schulz, Frank Himmelsbach, Ramamurthy Charubala, Wolfgang Pfleiderer

Journal:

Helvetica Chimica Acta

Year:

1999

Language:

english

File:

PDF, 211 KB

english, 1999

2

Nucleotides Part LXX : Inhibition of HIV-1 Replication by Chemically Synthesized, Nuclease-Resistant, Nontoxic (2′→5′)-Oligoadenylate Agonists

Ramamurthy Charubala, Wolfgang Pfleiderer, Robert J. Suhadolnik, Kathryn T. Iacono, Nicholas F. Muto, Joseph W. Homan, Camille Martinand-Mari, Susan E. Horvath, Earl E. Henderson, Amber Steele, Thomas

Journal:

Helvetica Chimica Acta

Year:

2002

Language:

english

File:

PDF, 191 KB

english, 2002

3

Synthese von (±)-Predicentrin

Ramamurthy Charubala, Bantwal Ramachandra Pai, Tuticorin Raghavachari Govindachari, Narayana Viswanathan

Journal:

European Journal of Inorganic Chemistry

Year:

1968

File:

PDF, 193 KB

1968

4

ChemInform Abstract: Nucleotides. Part 63. New 2-(4-Nitrophenyl)ethyl(Npe)- and 2-(4-Nitrophenyl)ethoxycarbonyl(Npeoc)-Protected 2′-Deoxyribonucleosides and Their 3′-Phosphoramidites — Versatile Building Blocks for Oligonucleotide Synthesis.

Holger Lang, Margarete Gottlieb, Michael Schwarz, Silke Farkas, Bernd S. Schulz, Frank Himmelsbach, Ramamurthy Charubala, Wolfgang Pfleiderer

Journal:

Year:

2000

File:

PDF, 26 KB

2000

5

ChemInform Abstract: Nucleotides. Part 70. Inhibition of HIV-1 Replication by Chemically Synthesized, Nuclease-Resistant, Nontoxic (2′→5′)-Oligoadenylate Agonists.

Ramamurthy Charubala, et al. et al.

Journal:

Year:

2002

File:

PDF, 27 KB

2002

6

Nucleotide. X. Synthese und Eigenschaften von Dinucleosidmonophosphaten mit 2′-Desoxyadenosin und 1-(2′-Desoxy-β-D-ribofuranosyl)-lumazinen als Bausteine

Ramamurthy Charubala, Wolfgang Pfleiderer

Journal:

Helvetica Chimica Acta

Year:

1979

File:

PDF, 941 KB

1979

7

Nucleotide. IX. Synthese und Eigenschaften von 1-(2′-Desoxy-D-ribofuranosyl)-lumazin-3′-monophosphaten

Ramamurthy Charubala, Wolfgang Pfleiderer

Journal:

Helvetica Chimica Acta

Year:

1979

File:

PDF, 497 KB

1979

8

Nucleotide. XV. Synthese und Eigenschaften von 2′-O-t-Butyldimethylsilyl-5′-O-monomethoxytritylribonucleosid-3′-phosphotriestern, Ausgangssubstanzen für Oligonucleotid-Synthesen

Gunter Silber, Dieter Flockerzi, Rajendra Singh Varma, Ramamurthy Charubala, Eugen Uhlmann, Wolfgang Pfleiderer

Journal:

Helvetica Chimica Acta

Year:

1981

File:

PDF, 753 KB

1981

9

Nucleotides. Part XXV. Chemical synthesis of the hexaribonucleotide C-A-A-C-C-A

Misuzu Lchiba, Ramamurthy Charubala, Rajendra S. Varma, Wolfgang Pfleiderer

Journal:

Helvetica Chimica Acta

Year:

1986

Language:

english

File:

PDF, 638 KB

english, 1986

10

Nucleotides. Part XXVII Bis[2-(p-nitrophenyl)ethyl] Phosphorochloridate, a New Versatile Phosphorylating Agent in Nucleotide Chemistry

Frank Himmelsbach, Ramamurthy Charubala, Wolfgang Pfleiderer

Journal:

Helvetica Chimica Acta

Year:

1987

Language:

english

File:

PDF, 628 KB

english, 1987

11

Nucleotides. Part XXVIII. Chemical syntheses of the 2′-5′-cordycepin-trimer core

Ramamurthy Charubala, Eugen Uhlmann, Frank Himmelsbach, Wolfgang Pfleiderer

Journal:

Helvetica Chimica Acta

Year:

1987

Language:

english

File:

PDF, 844 KB

english, 1987

12

Nucleotides part XXX Chemical synthesis of adenylyl-(2′ → 5′)-adenylyl-(2′ → 5′)-8-azidoadenosine, and activation and photoaffinity labelling of RNase L by [32P]p5′A2′p5′A2′p5′N38A

Ramamurthy Charubala, Wolfgang Pfleiderer, Robert W. Sobol, Shi Wu Li, Robert J. Suhadolnik

Journal:

Helvetica Chimica Acta

Year:

1989

Language:

english

File:

PDF, 511 KB

english, 1989

13

Nucleotides. Part. XXXII. Synthesis of 2′–5′ Connected oligonucleotides. Prodrugs for antiviral and antitumoral nucleosides

Piet Herdewijn, Ramamurthy Charubala, Erik De Clercq, Wolfgang Pfleiderer

Journal:

Helvetica Chimica Acta

Year:

1989

Language:

english

File:

PDF, 703 KB

english, 1989

14

Nucleotides. Part XXXI. Modified Oligomeric 2′–5′ A Analogues: Synthesis of 2′–5′ oligonucleotides with 9-(3′-azido-3′-deoxy-β-D-xylofuranosyl)adenine and 9-(3′-amino-3′-deoxy-β-D-xylofuranosyl)adenine as modified nucleosides

Piet Herdewijn, Ramamurthy Charubala, Wolfgang Pfleiderer

Journal:

Helvetica Chimica Acta

Year:

1989

Language:

english

File:

PDF, 785 KB

english, 1989

15

Nucleotides. Part XXXV. Synthesis of 3′-deoxyadenylyl-(2′–5′)-3′-deoxyadenyIyl-(2′–ω)-9-(ω-hydroxyalkyl)adenines

Sergey N. Mikhailov, Ramamurthy Charubala, Wolfgang Pfleiderer

Journal:

Helvetica Chimica Acta

Year:

1991

Language:

english

File:

PDF, 293 KB

english, 1991

16

Nucleotides. Part XXXVIII.. Syntheses and characterization of phosphorothioate analogues of (2′–5′) adenylate dimer and trimer and their 5′-O-monophosphates

Ramamurthy Charubala, Wolfgang Pfleiderer

Journal:

Helvetica Chimica Acta

Year:

1992

Language:

english

File:

PDF, 551 KB

english, 1992

17

Nucleosides. Part LIX. The 2-(4-nitrophenyl)ethylsulfonyl (Npes) Group: A New Type of Protection in Nucleoside Chemistry

Magdalena Pfister, Helga Schirmeister, Marion Mohr, Silke Farkas, Klaus-Peter Stengele, Tilman Reiner, Martin Dunkel, Surendra Gokhale, Ramamurthy Charubala, Wolfgang Pfleiderer

Journal:

Helvetica Chimica Acta

Year:

1995

Language:

english

File:

PDF, 2.71 MB

english, 1995

18

Nucleotides. Part XLV. Synthesis of new (2′–5′)adenylate trimers, containing 5′-amino-5′-deoxyadenosine residues at the 5′-end of the oligoadenylate chain, and of its analogues, carrying a 9-[(2-hydroxyethoxy)methyl]adenine residue at the 2′-terminus

Evgeny I. Kvasyuk, Tamara I. Kulak, Igor A. Mikhailopulo, Ramamurthy Charubala, Wolfgang Pfleiderer

Journal:

Helvetica Chimica Acta

Year:

1995

Language:

english

File:

PDF, 607 KB

english, 1995

19

Nucleotides. Part LXXVI : Synthesis and Properties of New Isoalloxazine (=Benzo[g]pteridine-2,4(1H,3H)-dione) Derivatives as Labels for Oligonucleotides

Evgeny Kvassiouk, Ramamurthy Charubala, Wolfgang Pfleiderer

Journal:

Helvetica Chimica Acta

Year:

2010

Language:

english

File:

PDF, 233 KB

english, 2010

20

Nucleotide, XII. Synthese und Eigenschaften von Trinucleosiddiphosphaten mit Thymidin, 2′-Desoxyadenosin und 1-(2′-Desoxy-α- sowie 1-(2′-Desoxy-β-D-ribofuranosyl)lumazinen als Bausteine

Ramamurthy Charubala, Willi Bannwarth, Wolfgang Pfleiderer

Journal:

European Journal of Organic Chemistry

Year:

1980

File:

PDF, 832 KB

1980

21

Nucleoside, XXXVII. Synthese und Eigenschaften von 2′-O- und 3′-O-(tert-Butyldi-methylsilyl)-5′-O-(4-methoxytrityl)- sowie 2′,3′-Bis-O-(tert-butyl-dimethylsilyl)ribonucleosiden — Ausgangssubstanzen für Oligoribonucleotid-Synthesen

Dieter Flockerzi, Gunter Silber, Ramamurthy Charubala, Wilhelm Schlosser, Rajendra Singh Varma, Frank Creegan, Wolfgang Pfleiderer

Journal:

European Journal of Organic Chemistry

Year:

1981

Language:

german

File:

PDF, 1.11 MB

german, 1981

22

Nucleotide, XVI. Synthese und Eigenschaften von Adenylyl-adenylyl-adenosinen

Ramamurthy Charubala, Eugen Uhlmann, Wolfgang Pfleiderer

Journal:

European Journal of Organic Chemistry

Year:

1981

File:

PDF, 967 KB

1981

23

(2′-5′)Oligoadenylate and intracellular immunity against retrovirus infection

Heinz C. Schröder, Robert J. Suhadolnik, Wolfgang Pfleiderer, Ramamurthy Charubala, Werner E.G. Müller

Journal:

International Journal of Biochemistry

Year:

1992

Language:

english

File:

PDF, 1.11 MB

english, 1992

24

The p-nitrophenylethyl (NPE) group: A versatile new blocking group for phosphate and aglycone protection in nucleosides and nucleotides

Frank Himmelsbach, Bernd S. Schulz, Thomas Trichtinger, Ramamurthy Charubala, Wolfgang Pfleiderer

Journal:

Year:

1984

Language:

english

File:

PDF, 1.67 MB

english, 1984

25

Synthesis and properties of 3′-deoxyadenylate trimer dA2′p5′A2′p5′A

Ramamurthy Charubala, Wolfgang Pfleiderer

Journal:

Tetrahedron Letters

Year:

1980

Language:

english

File:

PDF, 225 KB

english, 1980

26

A new solid phase approach for rapid syntheses of oligonucleotides bearing a 3′-terminal phosphate group

Eduard Felder, Robert Schwyzer, Ramamurthy Charubala, Wolfgang Pfleiderer, Bernd Schulz

Journal:

Tetrahedron Letters

Year:

1984

Language:

english

File:

PDF, 259 KB

english, 1984

27

Synthesis of a modified 2′, 5′-Adenylate trimer with a 2′,3′-Di-O-(2-Carboxyethyl)-ethylidene terminal group

Evgeny I. Kvasyuk, Tamara I. Kulak, Galina T. Zaitseva, Igor A. Mikhailopulo, Ramamurthy Charubala, Wolfgang Pfleiderer

Journal:

Tetrahedron Letters

Year:

1984

Language:

english

File:

PDF, 198 KB

english, 1984

28

Synthesis of a new 125I-labeled tyrosine methyl ester conjugate of adenylyl-(2′-5′)-adenylyl-(2′-5′)-[2′,3′-di-O-(2-carboxyethyl)ethylidene]adenosine

Evgeny I. Kvasyuk, Tamara I. Kulak, Svetlana M. Shulyakovskaya, Mikhail V. Makarenko, Igor A. Mikhailopulo, Charubala Ramamurthy, Wolfgang Pfleiderer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 217 KB

english, 1996

29

Synthesis of O6-p-nitrophenylethyl guanosine and 2′-deoxyguanosine derivatives

Thomas Trichtinger, Ramamurthy Charubala, Wolfgang Pfleiderer

Journal:

Tetrahedron Letters

Year:

1983

Language:

english

File:

PDF, 251 KB

english, 1983

30

Synthesis of inosinate trimer I2′p5′I2′pt′I and tetramer I2′p5′I2′p5′I2′p5′I

Ramamurthy Charubala, Wolfgang Pfleiderer

Journal:

Tetrahedron Letters

Year:

1982

Language:

english

File:

PDF, 419 KB

english, 1982

31

Synthesis and properties of adenylate trimers A2′p5′A2′p5′A, A2′p5′A3′p5′A and A3′p5′A2′p5′A

Ramamurthy Charubala, Wolfgang Pfleiderer

Journal:

Tetrahedron Letters

Year:

1980

Language:

english

File:

PDF, 212 KB

english, 1980

32

Synthesis of new modified 2′,5′-adenylate trimers carrying 3′-amino-3′-deoxyadenosine at the 2′-terminus

Wolfgang Pfleiderer, Frank Himmelsbach, Ramamurthy Charubala

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 383 KB

english, 1994

33

Inhibition of DNA topoisomerase I activity by 2′,5′-oligoadenylates and mismatched double-stranded RNA in uninfected and HIV-1-infected H9 cells

Heinz C. Schröder, Merike Kelve, Heike Schäcke, Wolfgang Pfleiderer, Ramamurthy Charubala, Robert J. Suhadolnik, Werner E.G. Müller

Journal:

Chemico-Biological Interactions

Year:

1994

Language:

english

File:

PDF, 1.20 MB

english, 1994

34

2′,5′-phosphodiesterase activity depends upon the presence of a 3′-hydroxyl moiety in the penultimate position of the oligonucleotide substrate

David Alster, Danuta Brozda, Yukio Kitade, Alice Wong, Ramamurthy Charubala, Wolfgang Pfleiderer, Paul F. Torrence

Journal:

Biochemical and Biophysical Research Communications

Year:

1986

Language:

english

File:

PDF, 275 KB

english, 1986

35

Inhibition of Epstein-Barr virus-associated nuclear antigen (EBNA) induction by (2′,5′)oligoadenylate and the cordycepin analog: Mechanism of action for inhibition of EBV-induced transformation

Earl E. Henderson, Paul W. Doetsch, Ramamurthy Charubala, Wolfgang Pfleiderer, Robert J. Suhadolnik

Journal:

Year:

1982

Language:

english

File:

PDF, 337 KB

english, 1982

36

Phosphorothioate analogs of (2'-5')(A)4: agonist and antagonist activities in intact cells

Charachon, Guillaume, Sobol, Robert W., Bisbal, Catherine, Salehzada, Tamim, Silhol, Michele, Charubala, Ramamurthy, Pfleiderer, Wolfgang, Lebleu, Bernard, Suhadolnik, Robert J.

Journal:

Year:

1990

Language:

english

File:

PDF, 1.58 MB

english, 1990

37

HIV-1 reverse transcriptase: Inhibition by 2',5'-oligoadenylates

Sobol, Robert W., Fisher, William L., Reichenbach, Nancy L., Kumar, Amalendra, Beard, William A., Wilson, Samuel H., Charubala, Ramamurthy, Pfleiderer, Wolfgang, Suhadolnik, Robert J.

Journal:

Year:

1993

Language:

english

File:

PDF, 1.32 MB

english, 1993

38

Phosphorothioate Analogs of 2–5A: Elucidation of the Stereochemical Course of the Enzymes of the 2–5A Synthetase/RNase L System

Karikó, Katalin, Li, Shu Wu, Sobol, Robert W., Suhadolnik, Lorraine, Reichenbach, Nancy L., Suhadolnik, Robert J., Charubala, Ramamurthy, Pfleiderer, Wolfgang

Journal:

Nucleosides and Nucleotides

Year:

1987

Language:

english

File:

PDF, 503 KB

english, 1987

39

Cordycepin analogs of 2',5'-oligoadenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase

Mueller, Werner E. G., Weiler, Barbara E., Charubala, Ramamurthy, Pfleiderer, Wolfgang, Leserman, Lee, Sobol, Robert W., Suhadolnik, Robert J., Schroeder, Heinz C.

Journal:

Year:

1991

Language:

english

File:

PDF, 1.77 MB

english, 1991

40

2′,5′-Adenylate and Cordycepin Trimer Cores: Metabolic Stability and Evidence for Antimitogenesis without 5′-Rephosphorylation

Suhadolnik, Robert J., Doetsch, Paul W., Devash, Yair, Henderson, Earl E., Charubala, Ramamurthy, Pfleiderer, Wolfgang

Journal:

Nucleosides and Nucleotides

Year:

1983

Language:

english

File:

PDF, 792 KB

english, 1983

41

Structural and Functional Features of the 37-kDa 2-5A-Dependent RNase L in Chronic Fatigue Syndrome

Shetzline, Susan E., Martinand-Mari, Camille, Reichenbach, Nancy L., Buletic, Zivjena, Lebleu, Bernard, Pfleiderer, Wolfgang, Charubala, Ramamurthy, De Meirleir, Kenny, De Becker, Pascale, Peterson, D

Journal:

Journal of Interferon & Cytokine Research

Year:

2002

Language:

english

File:

PDF, 484 KB

english, 2002

42

[Part 2: Biological Sciences] || Core (2′-5′)oligoadenylate and the Cordycepin Analog: Inhibitors of Epstein--Barr Virus-Induced Transformation of Human Lymphocytes in the Absence of Interferon

Paul W. Doetsch, Robert J. Suhadolnik, Yosuke Sawada, Joseph D. Mosca, Maryann B. Flick, Nancy L. Reichenbach, An Quoc Dang, Joseph M. Wu, Ramamurthy Charubala, Wolfgang Pfleiderer and Earl E. Henders

Journal:

Proceedings of the National Academy of Sciences

Year:

1981

Language:

english

File:

PDF, 892 KB

english, 1981

43

Phosphorothioate and Cordycepin Analogues of 2′,5′-oligoadenylate: Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Infection in vitro

David C. Montefiori, Robert W. Sobol, Shi Wu Li, Nancy L. Reichenbach, Robert J. Suhadolnik, Ramamurthy Charubala, Wolfgang Pfleiderer, Ann Modliszewski, W. Edward Robinson and William M. Mitchell

Journal:

Proceedings of the National Academy of Sciences

Year:

1989

Language:

english

File:

PDF, 744 KB

english, 1989

44

Phosphorothioate analogs of 2',5'-oligoadenylate. Enzymatically synthesized 2',5'-phosphorothioate dimer and trimer: unequivocal structural assignment and activation of 2',5'-oligoadenylate-dependent endoribonuclease

Kariko, Katalin, Sobol, Robert W., Suhadolnik, Lorraine, Li, Shi Wu, Reichenbach, Nancy Lee, Suhadolnik, Robert J., Charubala, Ramamurthy, Pfleiderer, Wolfgang

Journal:

Year:

1987

Language:

english

File:

PDF, 1.65 MB

english, 1987

45

Phosphorothioate analogs of 2',5'-oligoadenylate. Activation of 2',5'-oligoadenylate-dependent endoribonuclease by 2',5'-phosphorothioate cores and 5'-monophosphates

Kariko, Katalin, Li, Shi Wu, Sobol, Robert W., Suhadolnik, Robert J., Charubala, Ramamurthy, Pfleiderer, Wolfgang

Journal:

Year:

1987

Language:

english

File:

PDF, 1.86 MB

english, 1987

46

Inhibition of HIV Type 1 Replication in CD4 + and CD14 + Cells Purified from HIV Type 1-Infected Individuals by the 2-5A Agonist Immunomodulator, 2-5A N6B

Dimitrova, Dessislava I., Reichenbach, Nancy L., Yang, Xiaowei, Pfleiderer, Wolfgang, Charubala, Ramamurthy, Gaughan, John P., Suh, Byungse, Henderson, Earl E., Suhadolnik, Robert J., Rogers, Thomas J

Journal:

AIDS Research and Human Retroviruses

Year:

2007

Language:

english

File:

PDF, 873 KB

english, 2007

47

Recent Progress in Oligoribonucleotide Synthesis

Pfister, Magdalena, Farkas, Silke, Charubala, Ramamurthy, Pfleiderer, Wolfgang

Journal:

Nucleosides and Nucleotides

Year:

1988

Language:

english

File:

PDF, 220 KB

english, 1988

48

Cordycepin Analogs of 2–5 a as Activators of RNase L: Study of the Structural Requirements for RNase L Activation

Kariko, Katalin, Reichenbach, Nancy L., Suhadolnik, Robert J., Charubala, Ramamurthy, Pfleiderer, Wolfgang

Journal:

Nucleosides and Nucleotides

Year:

1987

Language:

english

File:

PDF, 212 KB

english, 1987

49

Pteridine Nucleosides—New Versatile Building Blocks in Oligonucleotide Synthesis

Charubala, Ramamurthy, Maurinsh, Juris, Rösler, Angelika, Melguizo, Manuel, Jungmann, Oliver, Gottlieb, Margarete, Lehbauer, Jörg, Hawkins, Mary, Pfleiderer, Wolfgang

Journal:

Nucleosides and Nucleotides

Year:

1997

Language:

english

File:

PDF, 419 KB

english, 1997

50

2′,5′-Phosphodiesterase Activity Depends Upon the Presence of a 3-Hydroxyl Moiety in the Penultimate Position of the Oligonucleotide Substrate

Alster, David, Brozda, Danuta, Kitade, Yukio, Wong, Alice, Charubala, Ramamurthy, Pfleiderer, Wolfgang, Torrence, Paul

Journal:

Nucleosides and Nucleotides

Year:

1987

Language:

english

File:

PDF, 109 KB

english, 1987